We have witnessed a wealth of conversation about what works regarding effective scaling and replication. We have also seen increasing acknowledgement of the dynamic ecosystems within which our complex work exists. In truth, there are myriad approaches that can bring about intended outcomes. Some approaches are in contexts that allow for a fixed solution, and for others, continuous innovation is required. The most appropriate strategy—and thus the most effective approach to measurement—will depend on the nature of the problem, the solution, and on the questions you are trying to answer. Engage with a diverse group of funders, evaluators, and innovators as we discuss the implications for our field.